Автореферат и диссертация по медицине (14.00.14) на тему:Поиск генов, вовлеченных в процессы метастазирования, методом дифференциального дисплея

ВВЕДЕНИЕ

ЛИТЕРАТУРНЫЙ ОБЗОР.

Введение.И молекулярно-биологические аспекты метастазирования.

Участие факторов роста в метастазировании.

Участие компонентов адгезивных структур в метастазировании.

Участие внеклеточных протеаз и их ингибиторов в метастазировании.

Гены, вовлеченные в индукцию метастазирования.

Гены, вовлеченные в супрессию метастазирования.

Онкогены и метастатический потенциал.

Участие онкогена ras в метастазировании.

Участие онкогена src в опухолевой прогрессии.

Регуляция активности Src-киназы фосфорилированием.

Способы активации Src.

Механизмы участия Src в опухолевой прогрессии.

Роль генов апоптоза в метастазировании.

Процессы везикулярного транспорта.

Белки, участвующие в везикулярном транспорте.

Участие Rab GTP-аз в процессах везикулярного транспорта.

Образование SNARE транс-комплекса и слияние мембран.

Seel белки.

Участие коатомеров в образовании транспортных везикул и их отделение.

Малые GTP-азы, вовлеченные в процессы везикулярного транспорта.

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