Автореферат и диссертация по медицине (14.00.06) на тему:Молекулярно-генетическое исследование инфаркта миокарда в популяции якутов

СПИСОК УСЛОВНЫХ ОБОЗНАЧЕНИЙ И СОКРАЩЕНИЙ.

ВВЕДЕНИЕ.

1. ОБЗОР ЛИТЕРАТУРЫ.

1.1. Факторы риска ишемической болезни сердца.

1.2. Генетические основы развития инфаркта миокарда.

1.3. Полиморфизм генов-кандидатов сердечно-сосудистых заболеваний.

1.3.1. Полиморфизм гена аполипопротеина Е.

1.3.2. Полиморфизм гена аполипопротеина В.

1.3.3. Полиморфизм гена липопротеинлипазы.

1.3.4. Полиморфизм гена белка переносчика эфиров холестерина.

1.3.5. Полиморфизм гена эндотелиальной синтазы окиси азота.

1.3.6. Полиморфизм гена параоксоназы 1.

1.3.7. Полиморфизм гена ангиотензин-превращающего фермента

1.3.8. Полиморфизм гена сосудистого рецептора ангиотензина II

1 типа.

2. ОБЪЕКТ И МЕТОДЫ ИССЛЕДОВАНИЯ.

2.1. Характеристика обследованных групп.

2.2. Методы исследования.

2.2.1. Антропометрия.

2.2.2. Измерение артериального давления.

2.2.3. Определение состава общих липидов.

2.2.4. Опрос о курении.

2.3. Молекулярно-генетические методы исследования.

2.3.1. Выделение ДНК из лейкоцитов периферической крови.

2.3.2. Амплификация полиморфных участков ДНК.

2.3.3. Электрофорез амплифицированных фрагментов ДНК.

2.3.4. Статистический анализ результатов исследования.

3. РЕЗУЛЬТАТЫ И ОБСУЖДЕНИЕ.

3.1. Факторы риска сердечно-сосудистых заболеваний в группе больных инфарктом миокарда.

3.2. Анализ ассоциаций полиморфных маркеров 2059С/Ти 2197С/Т гена аполипротеина Е с инфарктом миокарда.

3.3. Анализ ассоциаций полиморфных маркеров 34622С/Т и 41064A/G гена аполипопротеина В с инфарктом миокарда.

3.4. Анализ ассоциаций полиморфизма 22125T/G гена липопротеинлипазы с инфарктом миокарда.

3.5. Анализ ассоциаций полиморфизма 20200A/G а гена белка переносчика эфиров холестерина с инфарктом миокарда.

3.6. Анализ ассоциаций VNTR полиморфизма гена эндотелиальной синтазы окиси азота с инфарктом миокарда.

3.7. Анализ ассоциаций полиморфизма 16341G/A гена параоксоназы

1 с инфарктом миокарда.

3.8. Анализ ассоциаций I/D полиморфизма гена ангиотензин-превращающего фермента с инфарктом миокарда.

3.9. Анализ ассоциаций полиморфизма 1166А/С гена сосудистого рецептора ангиотензина II1 типа с инфарктом миокарда.

ЗЛО. Анализ ассоциаций сочетаний полиморфных маркеров генов-кандидатов сердечно-сосудистых заболеваний с инфарктом миокарда.

3.11. Анализ ассоциаций полиморфных маркеров генов-кандидатов сердечно-сосудистых заболеваний с липидным спектром крови.

3.12. Распределение частот генотипов и аллелей полиморфных маркеров генов-кандидатов сердечно-сосудистых заболеваний в популяции якутов в старческом возрасте.

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